Scottish monarch, queen consort of James V. Daughter of Claude of Lorraine, Duc de Guise and Antoinette of Bourbon, she was also known as Mary of Lorraine. She married Louis D'Orleans, duc de Longueville in 1534, by whom she had two sons. After the duc's death in 1537, she was persued for marriage by Henry VIII and James V. She allegedly refused Henry VIII's proposal by saying "I fear my neck is too small." She wed James V of Scotland by proxy in Paris in May of 1538, and in person at St. Andrews on June 12 of that year. Their two sons, James and Arthur, died within weeks of one another in 1541. The king died in December of 1542, a week after the birth of thier daughter and heir to the throne, Mary, Queen of Scots. Mary of Guise replaced the ineffectual James Hamilton, Earl of Aran as regent in 1554, and arranged for the marriage of her daughter to the French dauphin. A Roman Catholic, she persued pro-French policies, which embroiled her in civil war with the protestant Scottish nobles. She was deposed on religious grounds in 1559. Suffering from dropsy, Mary died at Edinburgh Castle at the age of 45. Her body was returned to France and given to her sister Renee, abbess of the Convent of Ste. Pierre (findagrave.com)