Mary first married John Wyatt, 1647, Farmington, Connecticut. John and Mary had at least six children, possibly more. They are: John II, Hepzibah, Dorcus, Sarah, Joanna, and Israel.

Following John's death in 1668, she married the widower, John Graves. They had one son, Nathaniel. John was killed by Indians during the attack on Hatfield, Massachusetts.

Mary next married Lieutenant William Allis, of Hatfield, Massachusetts, whose wife had been killed by the Indians, in 1677. They had no children. William died in 1678.

On March 16, 1681, she married Captain Samuel Gaylord, in Windsor, Connecticut. He was her fourth husband and they had no children.

Mary died a few days after Samuel.