At age 22 she married Uriah Morehouse Gregory M.D. and had the following ten children:
Mariett Gregory (1793-1861),
Charles Henry Gregory (1795-1866),
Lucretia Gregory (1798-1842),
Edward Ely Gregory (1800-1884),
Sherlock Shenstone Gregory (1802-1885),
William Melville Gregory (1804-1884),
George Follett Hopkins Gregory (1806-1837),
Thomas Hale Gregory (1808-1848),
John Ely Gregory (1811-1848),
Emily Worthington Gregory (1815-1900).